Quantum computing is accelerating
Partnerships with particle accelerators are heating up
Particle accelerator projects like the Large Hadron Collider (LHC) don’t just smash particles - they also power the invention of some of the world’s most impactful technologies. A favorite example is the world wide web, which was developed for particle physics experiments at CERN.
Tech designed to unlock the mysteries of the universe has brutally exacting requirements – and it is this boundary pushing, plus billion-dollar budgets, that has led to so much innovation.
For example, X-rays are used in accelerators to measure the chemical composition of the accelerator products and to monitor radiation. The understanding developed to create those technologies was then applied to help us build better CT scanners, reducing the x-ray dosage while improving the image quality.
Stories like this are common in accelerator physics, or High Energy Physics (HEP). Scientists and engineers working in HEP have been early adopters and/or key drivers of innovations in advanced cancer treatments (using proton beams), machine learning techniques, robots, new materials, cryogenics, data handling and analysis, and more.
A key strand of HEP research aims to make accelerators simpler and cheaper. A key piece of infrastructure that could be improved is their computing environments.
: “CERN is one of the most highly demanding computing environments in the research world... From software development, to data processing and storage, networks, support for the LHC and non-LHC experimental programme, automation and controls, as well as services for the accelerator complex and for the whole laboratory and its users, computing is at the heart of CERN’s infrastructure.”
, it’s no surprise that the HEP community is interested in quantum computing, which offers real solutions to some of their hardest problems.
As the authors of stated: “[Quantum Computing] encompasses several defining characteristics that are of particular interest to experimental HEP: the potential for quantum speed-up in processing time, sensitivity to sources of correlations in data, and increased expressivity of quantum systems... Experiments running on high-luminosity accelerators need faster algorithms; identification and reconstruction algorithms need to capture correlations in signals; simulation and inference tools need to express and calculate functions that are classically intractable.”
The HEP community’s interest in quantum computing is growing. In recent years, their scientists have been looking carefully at how quantum computing could help them, publishing a number of papers discussing the challenges and requirements for quantum technology to make a dent ( and here’s the Dz).
In the past few months, what was previously theoretical is becoming a reality. Several groups published results using quantum machines to tackle something called “Lattice Gauge Theory”, which is a type of math used to describe a broad range of phenomena in HEP (and beyond). Two papers came from academic groups using quantum simulators, one using and one using . Another group, including scientists from Google, tackled Lattice Gauge Theory using a Taken together, these papers indicate a growing interest in using quantum computing for High Energy Physics, beyond simple one-dimensional systems which are more easily accessible with classical methods such as tensor networks.
We have been working with DESY, one of the world’s leading accelerator centers, to help make quantum computing useful for their work. DESY, short for Deutsches Elektronen-Synchrotron, is a national research center that operates, develops, and constructs particle accelerators, and is part of the worldwide computer network used to store and analyze the enormous flood of data that is produced by the LHC in Geneva.
Our first publication from this partnership describes a quantum machine learning technique for untangling data from the LHC, finding that in some cases the quantum approach was indeed superior to the classical approach. as it’s a favorite contender for quantum advantage in HEP.
Lattice Gauge Theories are one approach to solving what are more broadly referred to as “quantum many-body problems”. Quantum many-body problems lie at the border of our knowledge in many different fields, such as the electronic structure problem which impacts chemistry and pharmaceuticals, or the quest for understanding and engineering new material properties such as light harvesting materials; to basic research such as high energy physics, which aims to understand the fundamental constituents of the universe, or condensed matter physics where our understanding of things like high-temperature superconductivity is still incomplete.
The difficulty in solving problems like this – analytically or computationally – is that the problem complexity grows exponentially with the size of the system. For example, there are 36 possible configurations of two six-faced dice (1 and 1 or 1 and 2 or 1and 3... etc), while for ten dice there are more than sixty million configurations.
Quantum computing may be very well-suited to tackling problems like this, due to a quantum processor’s similar information density scaling – with the addition of a single qubit to a QPU, the information the system contains doubles. Our 56-qubit System Model H2, for example, can hold quantum states that require 128*(2^56) bits worth of information to describe (with double-precision numbers) on a classical supercomputer, which is more information than the biggest supercomputer in the world can hold in memory.
The joint team made significant progress in approaching the Lattice Gauge Theory corresponding to Quantum Electrodynamics, the theory of light and matter. For the first time, they were able study the full wavefunction of a two-dimensional confining system with gauge fields and dynamical matter fields on a quantum processor. They were also able to visualize the confining string and the string-breaking phenomenon at the level of the wavefunction, across a range of interaction strengths.
The team approached the problem starting with the definition of the Hamiltonian using the InQuanto software package, and utilized the reusable protocols of InQuanto to compute both projective measurements and expectation values. InQuanto allowed the easy integration of measurement reduction techniques and scalable error mitigation techniques. Moreover, the emulator and hardware experiments were orchestrated by the Nexus online platform.
In one section of the study, a circuit with 24 qubits and more than 250 two-qubit gates was reduced to a smaller width of 15 qubits thanks our unique qubit re-use and mid-circuit measurement automatic compilation implemented in TKET.
This work paves the way towards using quantum computers to study lattice gauge theories in higher dimensions, with the goal of one day simulating the full three-dimensional Quantum Chromodynamics theory underlying the nuclear sector of the Standard Model of particle physics. Being able to simulate full 3D quantum chromodynamics will undoubtedly unlock many of Nature’s mysteries, from the Big Bang to the interior of neutron stars, and is likely to lead to applications we haven’t yet dreamed of.
About ˰
˰, the world’s largest integrated quantum company, pioneers powerful quantum computers and advanced software solutions. ˰’s technology drives breakthroughs in materials discovery, cybersecurity, and next-gen quantum AI. With over 500 employees, including 370+ scientists and engineers, ˰ leads the quantum computing revolution across continents.
- Mitsui & Co. and Mitsubishi Electric demonstrated one of the world’s largest approximate Quantum Fourier Transforms (QFT) on ˰ ˰, scaling from prior records to 98 physical qubits.
- The collaboration also implemented a logical QFT using a QEC (Quantum Error Correction) code with up to 12 logical qubits.
- The work highlights ˰’s accuracy and flexible architecture.
While there is ongoing debate around the pace of quantum computing’s development, a more grounded way to assess progress is through concrete demonstrations of foundational algorithms at meaningful scale. In this context, Mitsui & Co. and Mitsubishi Electric are taking a pragmatic view of quantum progress—focusing on how close the field is to executing core algorithmic primitives that underpin many potential industrial applications, rather than relying on abstract milestones or timelines.
, the industrial giants teamed up with ˰ to measure how close we are to running the Quantum Fourier Transform (QFT), a widely-used algorithmic primitive, at scales necessary for industrial applications. In the process, the team successfully ran one of the largest instances of the approximate QFT ever demonstrated. This achievement matters because the QFT is an essential primitive that underpins many of the quantum algorithms expected to deliver practical advantages.
You may have heard of the (classical) Fourier transform (FT), due to its ubiquity throughout modern computing. The FT is essential in everything from image analysis to data compression, with almost limitless applications in between. The quantum Fourier transform (QFT) is similar; it’s used in everything from chemistry to finance.
Because the QFT is a foundational primitive underpinning many quantum algorithms, demonstrating it at larger scales and higher fidelity is a practical way to measure quantum computing readiness. This is exactly the type of benchmarking that organizations should consider to understand where today’s systems are useful, and to see how fault-tolerant approaches are progressing. Ultimately, algorithm-level benchmarking like this is one of the most useful ways to understand not just where we are, but where we are going.
A Transformative Approach
Primitives like Fourier Transform are so widespread because they simplify problems by transforming them into something that is easier to deal with. At ˰, not only are they crucial for industrial applications but they can also simplify algorithms, making them possible to run now instead of later. This ‘transformational’ approach extends beyond the QFT - other transforms exist, and we have even invented our own quantum-native transforms.
Using our ˰ quantum computer and Guppy language, the joint team explored running the QFT on both physical qubits and on logical qubits, showing that fault tolerance is progressing quickly. Running the QFT on 98 physical qubits; the paper shows a clear progression from previous results.
Then, using the Steane code, one of the best-studied quantum error correcting codes, the team used ˰’ 98 physical qubits to form 12 logical qubits, successfully running the QFT with the mechanisms of quantum error correction interwoven into the algorithm. This marks a crucial step forward for the field.
Foundational Progress
Taken together, these results provide a more concrete lens through which to view progress in quantum computing: not as abstract projections, but as measurable advances in the execution of foundational algorithms at increasing scale. By benchmarking the Quantum Fourier Transform on both physical and logical qubits, Mitsui & Co. and Mitsubishi Electric are helping to clarify what today’s hardware can already achieve, and where fault-tolerant approaches begin to extend those limits.
More broadly, the organizations best positioned to benefit from quantum computing will be those that focus on these foundational capabilities early, and use them to build a clear, evidence-based understanding of how the technology fits into their business goals.
It is believed that unlocking answers to some of the most complex scientific and industrial problems will require the seamless integration of high-performance computing (HPC), generative AI (GenAI), and quantum computing. Toward this goal, ˰, NVIDIA, and a major pharmaceutical company have successfully demonstrated the first step in a proof-of-principle framework designed to connect these three distinct computing paradigms for industrially relevant computational chemistry.
This milestone, enabled by three industry leaders and experts in their respective domains, serves as a foundational capability that could support the development of future hybrid quantum-AI workflows to help optimize industrial research and development (R&D).
The potential value is a path toward more automated, repeatable, and scalable workflows for translating chemistry problems into executable quantum programs—capabilities that could eventually make hybrid computing easier to deploy in industrial R&D.
The GenQAI Framework
The framework, termed Generative Quantum AI (GenQAI), involved a quantum computer simulating a pharmaceutical compound using programming instructions generated by an AI model, which itself was trained on quantum data that was simulated using HPC.
While the vision for GenQAI explores how future industrial simulation workflows might be optimized by training AI models using quantum data derived directly from a quantum computer, the framework currently consists of four main technical steps:
- Simulating quantum data: The process began by simulating quantum data with NVIDIA accelerated computing using .
- Fine-tuning the AI: This simulated quantum data was used to fine-tune a pre-trained AI model from the open .
- Generating instructions: The AI model then generated quantum circuits, which are the programming instructions required for the quantum simulation.
- Validating accuracy: To validate the results, the circuits were run on ˰’s ˰ quantum computer using its InQuanto quantum chemistry platform.
The core novelty of this development lies within the process of the framework itself. In this proof-of-principle experiment, an AI model fine-tuned on simulated quantum data generated circuits that were successfully executed and validated on ˰’s ˰ system. Rather than delivering an immediate commercial advantage, this achievement establishes a credible, verifiable baseline for how HPC, AI, and quantum computing can function in tandem.
The Case Study
The validation of the framework represents an early step toward the goal of developing scalable architectures for the pharmaceutical industry.
With a shared view toward eventually scaling the framework for pharmaceutical R&D applications, the researchers simulated a pharmaceutical compound: imipramine. This anti-depressant was chosen because it serves as a model compound for drug degradation and shelf-life studies, which are standard components of the pharmaceutical R&D lifecycle.
Developing hybrid infrastructure that enterprises may adopt requires a deep, coordinated effort among domain experts. As such, this successful test highlights the value of combining the strengths of a quantum computing hardware and software leader (˰), with a hybrid-quantum classical platform (NVIDIA), and a leading enterprise end-user to build and test future computing capabilities for industrial chemistry.
Scaling the Framework
Although demonstrated on a pharmaceutical compound, the architecture could eventually inform similar molecular-simulation workflows in sectors such as energy, agriculture, advanced materials, and electronics. At this stage, it provides a reference for further testing and development.
Engage Further
here to explore the full technical details of this demonstration and contact our team to learn more about joining ˰’s enterprise partner network.
˰ is pleased to announce that applications are now open for the ˰ SG Grand Challenge 2026, a global innovation challenge designed to bring together researchers, developers, scientists and innovators to explore practical applications of quantum computing.
Organized by ˰ and supported by Singapore's National Quantum Office and Aqora, the three-month program aims to foster collaboration across academia, industry and the quantum developer community while supporting the continued growth of Singapore's quantum ecosystem.
A Platform for Quantum Computing Innovation
Participants will work in teams to develop solutions across a range of challenge areas, including chemistry and molecular simulation, optimization, AI for quantum systems, quantum error correction, condensed matter and materials science, and open innovation. Throughout the program, participants will have access to mentoring, technical enablement and ˰ quantum computing resources.
Singapore Grand Finale
Selected finalist teams will be invited to present their work at the Grand Finale hosted in Singapore before representatives from academia, and industry. The event will celebrate innovative applications of quantum computing while providing an opportunity for participants to engage with Singapore's growing quantum community.
Join the Challenge
The ˰ SG Grand Challenge welcomes participants from around the world. Whether you are an experienced quantum researcher or beginning your quantum computing journey, the program offers an opportunity to collaborate, learn and contribute to the development of practical quantum applications.
Applications are now open. Spaces are limited and subject to review and approval.